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Among them, GPX1-4 and 6 are selenocysteine-containing proteins

The Role of Inflammation in Scalp Health Chronic, low-grade inflammation is often the silent enemy of a healthy head of hair

However, growing evidence indicates that alternative metabolic routes such as malic enzyme 1 (ME1), isocitrate dehydrogenases (IDH1 and IDH2), and the folate cycle also significantly contribute to NADPH production, particularly under stress conditions or during metabolic reprogramming [43]

Our analysis revealed a surprising overlap between proteins downregulated upon BSO treatment and mitochondrial GSH depletion, suggesting that most of the proteomic changes that occur upon cellular GSH depletion are likely due to mitochondrial effects (Fig